Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.63 |
| ▸ | FLT1 | P17948 | 2/20 | 0.63 |
| ▸ | FLT4 | P35916 | 1/20 | 0.63 |
| ▸ | CDK2 | P24941 | 9/20 | 0.45 |
| ▸ | IGF1R | P08069 | 2/20 | 0.45 |
| ▸ | CDK9 | P50750 | 7/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.43 |
| ▸ | FLT3 | P36888 | 9/20 | 0.43 |
| ▸ | CDK1 | P06493 | 6/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.43 |
| ▸ | CDK7 | P50613 | 5/20 | 0.42 |
| ▸ | AURKA | O14965 | 4/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.42 |
| ▸ | CDK4 | P11802 | 3/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | LDLR | P01130 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6070240 | 0.93 | KDR (0.54) | KDRFLT1FLT4FLT3PDGFRB | |
| SCHEMBL6069873 | 0.92 | KDR (0.53) | KDRFLT1FLT4FLT3PDGFRB | |
| SCHEMBL6069930 | 0.91 | KDR (0.52) | KDRFLT1FLT4CDK2IGF1R | |
| SCHEMBL6070209 | 0.88 | KDR (0.48) | KDRFLT1FLT4CDK2CDK9 | |
| SCHEMBL6070303 | 0.87 | FLT1 (0.47) | KDRFLT1FLT4CDK2IGF1R | |
| SCHEMBL6070891 | 0.86 | KDR (0.49) | KDRFLT1FLT4CDK2FLT3 | |
| SCHEMBL6070385 | 0.85 | KDR (0.45) | KDRFLT1FLT4CDK2CDK4 | |
| SCHEMBL6070296 | 0.85 | FLT1 (0.46) | KDRFLT1FLT4CDK2IGF1R | |
| SCHEMBL6070287 | 0.83 | KDR (0.44) | KDRFLT1FLT4PDGFRBGSK3B | |
| SCHEMBL6071031 | 0.83 | KDR (0.43) | KDRFLT1FLT4PDGFRBLDLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109204-B2 | controlling signal transduction; anticancer agents, antitumor agents, atherosclerosis, vision defects, antidiabetic agents, antiinflammatory agents | MERCK & CO., INC. (US) | 2006-09-19 | — | — | US | disclosed |