Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | FLT1 | P17948 | 2/20 | 0.45 |
| ▸ | FLT4 | P35916 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 9/20 | 0.45 |
| ▸ | JAK3 | P52333 | 7/20 | 0.45 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6070077 | 0.92 | JAK2 (0.45) | KDRFLT1FLT4JAK2JAK3 | |
| SCHEMBL6070209 | 0.89 | KDR (0.48) | KDRFLT1FLT4JAK2JAK3 | |
| SCHEMBL6069873 | 0.85 | KDR (0.53) | KDRFLT1FLT4JAK2JAK3 | |
| SCHEMBL6070012 | 0.85 | KDR (0.63) | KDRFLT1FLT4JAK2JAK3 | |
| SCHEMBL6070240 | 0.84 | KDR (0.54) | KDRFLT1FLT4JAK2JAK3 | |
| SCHEMBL6070891 | 0.83 | KDR (0.49) | KDRFLT1FLT4JAK2JAK3 | |
| SCHEMBL6070015 | 0.80 | JAK2 (0.44) | KDRFLT1FLT4JAK2JAK3 | |
| SCHEMBL6070069 | 0.79 | CDK2 (0.53) | KDRFLT1FLT4JAK2SYK | |
| SCHEMBL6070287 | 0.77 | KDR (0.44) | KDRFLT1FLT4JAK2JAK3 | |
| SCHEMBL6069753 | 0.76 | KCNH2 (0.43) | KDRJAK2JAK3SYKGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109204-B2 | controlling signal transduction; anticancer agents, antitumor agents, atherosclerosis, vision defects, antidiabetic agents, antiinflammatory agents | MERCK & CO., INC. (US) | 2006-09-19 | — | — | US | disclosed |