Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.45 |
| ▸ | JAK3 | P52333 | 7/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6070385 | 0.92 | KDR (0.45) | JAK2JAK3ACHEBACE1SYK | |
| SCHEMBL6070015 | 0.89 | JAK2 (0.44) | JAK2JAK3SYKGSK3BKDR | |
| SCHEMBL6070287 | 0.85 | KDR (0.44) | JAK2JAK3SYKGSK3BKDR | |
| SCHEMBL6069930 | 0.85 | KDR (0.52) | JAK2JAK3SYKGSK3BKDR | |
| SCHEMBL6071031 | 0.83 | KDR (0.43) | JAK2JAK3SYKGSK3BKDR | |
| SCHEMBL6069836 | 0.83 | FLT1 (0.40) | JAK2JAK3SYKGSK3BKDR | |
| SCHEMBL6070209 | 0.80 | KDR (0.48) | JAK2JAK3SYKGSK3BKDR | |
| SCHEMBL6070201 | 0.77 | SYK (0.41) | JAK2JAK3SYKGSK3BKDR | |
| SCHEMBL6069873 | 0.77 | KDR (0.53) | JAK2JAK3SYKGSK3BKDR | |
| SCHEMBL6070012 | 0.76 | KDR (0.63) | JAK2JAK3GSK3BKDRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109204-B2 | controlling signal transduction; anticancer agents, antitumor agents, atherosclerosis, vision defects, antidiabetic agents, antiinflammatory agents | MERCK & CO., INC. (US) | 2006-09-19 | — | — | US | disclosed |