Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 8/20 | 0.46 |
| ▸ | CA2 | P00918 | 8/20 | 0.46 |
| ▸ | CA4 | P22748 | 8/20 | 0.46 |
| ▸ | CA6 | P23280 | 8/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6071395 | 0.89 | AURKA (0.50) | AURKAAURKBMAPK10RIPK1DYRK1A | |
| Hydrochloric Acid SCHEMBL6070901 | 0.87 | AURKA (0.49) | AURKAAURKBMAPK10RIPK1DYRK1A | |
| SCHEMBL6070660 | 0.82 | KDM4E (0.62) | AURKAAURKBMAPK10RIPK1KDM4E | |
| SCHEMBL5582984 | 0.71 | MAPK10 (0.61) | AURKAAURKBMAPK10RIPK1DYRK1A | |
| SCHEMBL42245 | 0.71 | FLT3 (0.65) | CTNNB1WNT3AKDM4EALDH1A1CCNA2 | |
| SCHEMBL29444537 | 0.71 | FLT3 (0.65) | CTNNB1WNT3AKDM4EALDH1A1CCNA2 | |
| SCHEMBL6071119 | 0.70 | AURKA (0.68) | AURKAAURKBMAPK10RIPK1KDM4E | |
| Hydrochloric Acid SCHEMBL4258298 | 0.70 | FLT3 (0.63) | CTNNB1WNT3AKDM4EALDH1A1CCNA2 | |
| SCHEMBL27541852 | 0.70 | FLT3 (0.63) | CTNNB1WNT3AKDM4EALDH1A1CCNA2 | |
| Hydrazine SCHEMBL27690059 | 0.68 | FLT3 (0.61) | CTNNB1WNT3AKDM4EALDH1A1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K1, MAP3K19, MAP3K20 | AURKA 249/4885AURKB 369/4885MAPK10 387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.