Sugi Predict

Sugi Predict / Compounds / SCHEMBL607203

SCHEMBL607203

SCHEMBL607203

Cc1ccc(CC(Cl)Cl)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IDO1 P14902 1/20 0.46
▸ CYP1A2 P05177 1/20 0.42
▸ CYP2A6 P11509 1/20 0.42
▸ TAAR1 Q96RJ0 1/20 0.42
▸ ACHE P22303 1/20 0.42
▸ TDP1 Q9NUW8 1/20 0.42
▸ AGXT P21549 2/20 0.41
▸ TP53 P04637 1/20 0.40
▸ MAPT P10636 1/20 0.40
▸ PPARG P37231 1/20 0.40
▸ PPARA Q07869 1/20 0.40
▸ ALDH1A1 P00352 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ POLB P06746 1/20 0.39
▸ SLC6A2 P23975 1/20 0.38
▸ SLC6A3 Q01959 1/20 0.38
▸ HCRTR2 O43614 1/20 0.38
▸ ACACB O00763 1/20 0.37
▸ CYP19A1 P11511 1/20 0.36
▸ CYP11B1 P15538 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzene SCHEMBL6557696 0.82 CA2 (0.42) CYP1A2ACHETDP1PPARGPPARA
SCHEMBL6832904 0.80 IDO1 (0.42) IDO1CYP1A2CYP2A6TAAR1ACHE
SCHEMBL10659103 0.79 TSHR (0.54) CYP2A6TAAR1TDP1TP53PPARG
SCHEMBL11115722 0.78 IDO1 (0.41) IDO1CYP1A2CYP2A6TAAR1ACHE
SCHEMBL1579896 0.77 IDO1 (0.39) IDO1CYP1A2CYP2A6TAAR1ACHE
SCHEMBL11604508 0.77 HCRTR2 (0.41) IDO1CYP1A2CYP2A6TAAR1PPARG
SCHEMBL196656 0.76 PTGS1 (0.48) IDO1CYP1A2CYP2A6TAAR1ACHE
SCHEMBL8322312 0.76 SLC6A4 (0.61) IDO1CYP2A6TAAR1TDP1AGXT
SCHEMBL5496261 0.76 PTGS1 (0.48) IDO1CYP1A2CYP2A6TAAR1ACHE
SCHEMBL10707889 0.75 CYP1A2 (0.50) IDO1CYP1A2CYP2A6TAAR1ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0190987-A2 Process for the production of beta-carbolines by dehydrogenation SCHERING AKTIENGESELLSCHAFT (DE) 1986-08-13 — — EP claimed
US-8524906-B2 Tetrahydrothiazolopyridine inhibitors of phosphatidylinositol 3-kinase VERTEX PHARMACEUTICALS INCORPORATED (US) 2013-09-03 — — US disclosed
US-8148367-B2 Renin inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2012-04-03 — — US disclosed
US-20120039849-A1 TETRAHYDROTHIAZOLOPYRIDINE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE VERTEX PHARMACEUTICALS INCORPORATED (US) 2012-02-16 — — US disclosed
EP-2398810-A1 TETRAHYDROTHIAZOLOPYRIDINE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE Vertex Pharmaceuticals Incorporated (US) 2011-12-28 — — EP disclosed
WO-2010096389-A1 TETRAHYDROTHIAZOLOPYRIDINE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE VERTEX PHARMACEUTICALS INCORPORATED (US) 2010-08-26 — — WO disclosed
US-20100105665-A1 RENIN INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-04-29 — — US disclosed
US-7521464-B2 Pyrazole compounds for treatment of neurodegenerative disorders PFIZER INC. (US) 2009-04-21 — — US disclosed
WO-2008089005-A2 RENIN INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-07-24 — — WO disclosed
US-20070270474-A1 drugs have beta-amyloid peptide production inhibitory activity, such as 2-(2-benzo[b]thiophen-4-yl-acetylamino)-N-(5-phenyl-2H-pyrazol-3-yl)-propionamide, useful for treatment of Alzheimer's disease and Down's Syndrome PFIZER INC. 2007-11-22 — — US disclosed
US-4689390-A AMINE-EPOXY ADDUCT REACTED WITH PHENOLIC RESIN, ONE-PACK ASAHI DENKA KOGYO K.K. (JP) 1987-08-25 — — US disclosed
US-4657947-A COVERING RUSTY METAL SURFACES ASAHI DENKA KOGYO K.K. (JP) 1987-04-14 — — US disclosed
US-4657953-A CORROSION RESISTANCE ASAHI DENKA KOGYO K.K. (JP) 1987-04-14 — — US disclosed
EP-0197458-A2 Curable epoxy resin composition ASAHI DENKA KOGYO KABUSHIKI KAISHA (JP) 1986-10-15 — — EP disclosed
US-4535103-A POLYEPOXIDES AND EPOXY RESINS CROSSLINKED AND HARDENED WITH PHOSPHOROUS COMPOUNDS, AMINES, AND DIISOCYANATES ASAHI DENKA KOGYO K.K. (JP) 1985-08-13 — — US disclosed
US-4530947-A A RUSTY METAL-ADHERING CURABLE MIXTURE OF EPOXIDE-POLYHYDROXIDE REACTION PRODUCT, POLYISOCYANATE AND BITUMINOUS MATERIAL ASAHI DENKA KOGYO K.K. (JP) 1985-07-23 — — US disclosed
US-4411985-A TRIARYLPHOSPHINES OR TRIARYLPHOSPHORANES STABILIZERS EASTMAN KODAK COMPANY (US) 1983-10-25 — — US disclosed
US-4371633-A Coating composition for roads and other surfaces comprising chlorinated rubber, chlorinated paraffin and amorphous silica SOLTYSYK ALEX N 1983-02-01 — — US disclosed
US-4340716-A EPOXY RESINS AND HARDENERS ASAHI DENKA KOGYO K.K. (JP) 1982-07-20 — — US disclosed
US-3950451-A COUPLED PRODUCT OF ALKYLPHENOL AND PHENOL-FORMALDEHYDE-DIAMINE CONDENSATE ASAHI DENKA KOGYO K.K. (JA) 1976-04-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100105665-A1 RENIN INHIBITORS REN, ACE, AGT IDO1 3862/4885CYP1A2 292/4885CYP2A6 193/4885
US-20120039849-A1 TETRAHYDROTHIAZOLOPYRIDINE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE PIK3CA, PIK3CD, PIK3CG IDO1 3257/4885CYP1A2 2246/4885CYP2A6 2901/4885
US-20070270474-A1 drugs have beta-amyloid peptide production inhibitory activity, such as 2-(2-benzo[b]thiophen-4-yl-acetylamino)-N-(5-phenyl-2H-pyrazol-3-yl)-propionamide, useful for treatment of Alzheimer's disease and Down's Syndrome APP, BACE1, PSEN1 IDO1 3291/4885CYP1A2 2320/4885CYP2A6 3217/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.