Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP46A1 | Q9Y6A2 | 4/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6072449 | 0.77 | HCAR2 (0.50) | CYP46A1EPHX2KDM4ETP53L3MBTL1 | |
| SCHEMBL5801425 | 0.77 | HSD17B10 (0.41) | CYP46A1KDM4ETP53L3MBTL1RXFP1 | |
| SCHEMBL6072297 | 0.76 | CYP46A1 (0.44) | CYP46A1EPHX2KDM4EL3MBTL1P2RX7 | |
| SCHEMBL5802241 | 0.75 | KDM4E (0.48) | CYP46A1KDM4EP2RX7PHGDHTRPV1 | |
| SCHEMBL13683685 | 0.68 | CHRM1 (0.49) | KDM4EP2RX7MEN1KMT2APHGDH | |
| SCHEMBL15775448 | 0.67 | NPC1 (0.56) | KDM4ETP53L3MBTL1RXFP1THRB | |
| Hydrochloric Acid SCHEMBL3859591 | 0.67 | CHRM1 (0.48) | CYP46A1KDM4ETP53P2RX7MEN1 | |
| SCHEMBL5820284 | 0.66 | KDM4E (0.48) | CYP46A1KDM4EPHGDHGSK3B | |
| SCHEMBL16111150 | 0.65 | PHGDH (0.45) | KDM4EP2RX7PHGDH | |
| SCHEMBL14860965 | 0.65 | HRH3 (0.61) | L3MBTL1P2RX7PHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060116368-A1 | 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-01 | — | — | US | claimed |
| US-20060116368-A1 | 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116368-A1 | 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor | VDAC1, TRPV1, HVCN1 | CYP46A1 3558/4885EPHX2 3203/4885KDM4E 2664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.