Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP46A1 | Q9Y6A2 | 3/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | PHGDH | O43175 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 4/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6072449 | 0.81 | HCAR2 (0.50) | CYP46A1EPHX2PHGDHP2RX7GSK3B | |
| SCHEMBL5802241 | 0.79 | KDM4E (0.48) | CYP46A1PHGDHP2RX7GSK3BTRPV1 | |
| SCHEMBL6072204 | 0.76 | CYP46A1 (0.41) | CYP46A1EPHX2PHGDHP2RX7GSK3B | |
| SCHEMBL5803071 | 0.73 | SMN1; SMN2 (0.56) | CYP46A1MAPTKMT2AALDH1A1HSD17B10 | |
| SCHEMBL13683685 | 0.71 | CHRM1 (0.49) | PHGDHP2RX7TRPV1MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL3859591 | 0.70 | CHRM1 (0.48) | CYP46A1PHGDHP2RX7TRPV1MAPT | |
| SCHEMBL5820284 | 0.69 | KDM4E (0.48) | CYP46A1PHGDHGSK3BKDM4EHSD17B10 | |
| SCHEMBL15488697 | 0.68 | POLB (0.52) | PHGDHP2RX7TRPV1MAPTKDM4E | |
| SCHEMBL14860965 | 0.68 | HRH3 (0.61) | PHGDHP2RX7L3MBTL1 | |
| SCHEMBL16111150 | 0.68 | PHGDH (0.45) | PHGDHP2RX7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060116368-A1 | 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-01 | — | — | US | claimed |
| US-20060116368-A1 | 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116368-A1 | 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor | VDAC1, TRPV1, HVCN1 | CYP46A1 3558/4885EPHX2 3203/4885PHGDH 3571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.