Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.68 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | ME3 | Q16798 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.48 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5802659 | 0.93 | TRPV1 (0.76) | TRPV1EPHX2ME3HSD17B10KDM4E | |
| SCHEMBL5802992 | 0.93 | TRPV1 (0.75) | TRPV1EPHX2ME3HSD17B10KDM4E | |
| SCHEMBL5799801 | 0.87 | TRPV1 (0.82) | TRPV1EPHX2ME3MAPTMEN1 | |
| SCHEMBL5802548 | 0.85 | TRPV1 (0.68) | TRPV1EPHX2ME3HSD17B10KDM4E | |
| SCHEMBL6072388 | 0.82 | TRPV1 (0.64) | TRPV1EPHX2ME3HSD17B10KDM4E | |
| SCHEMBL5802617 | 0.81 | TRPV1 (1.00) | TRPV1EPHX2HSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL5802498 | 0.81 | TRPV1 (0.62) | TRPV1EPHX2HSD17B10KDM4ENPC1 | |
| SCHEMBL845869 | 0.81 | KDR (0.64) | TRPV1HSD17B10KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL23360626 | 0.79 | EPHX2 (0.59) | TRPV1EPHX2HSD17B10KDM4ENPC1 | |
| SCHEMBL23360653 | 0.79 | EPHX2 (0.59) | TRPV1EPHX2HSD17B10KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060116368-A1 | 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116368-A1 | 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor | VDAC1, TRPV1, HVCN1 | TRPV1 2/4885EPHX2 3203/4885ME3 2330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.