Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 8/20 | 0.52 |
| ▸ | KDR | P35968 | 9/20 | 0.51 |
| ▸ | BRAF | P15056 | 9/20 | 0.51 |
| ▸ | RET | P07949 | 4/20 | 0.51 |
| ▸ | ABL1 | P00519 | 3/20 | 0.51 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.51 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.51 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | HTR2C | P28335 | 3/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.51 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL546123 | 0.87 | BRAF (0.52) | RAF1KDRBRAFRETABL1 | |
| SCHEMBL6072502 | 0.85 | RAF1 (0.69) | RAF1KDRBRAFRETABL1 | |
| SCHEMBL6071951 | 0.85 | KDR (0.67) | RAF1KDRBRAFRETABL1 | |
| SCHEMBL14793013 | 0.82 | KDR (0.61) | RAF1KDRBRAFRETABL1 | |
| SCHEMBL1659057 | 0.81 | MAPK14 (0.75) | RAF1KDRBRAFRETABL1 | |
| SCHEMBL6072111 | 0.80 | KDR (0.53) | RAF1KDRBRAFABL1MAPK14 | |
| SCHEMBL6071911 | 0.80 | RAF1 (0.57) | RAF1KDRBRAFRETABL1 | |
| SCHEMBL1660255 | 0.80 | RAF1 (0.79) | RAF1KDRBRAFRETABL1 | |
| SCHEMBL6072483 | 0.79 | KDR (0.61) | RAF1KDRBRAFRETABL1 | |
| SCHEMBL14793075 | 0.79 | KDR (0.70) | RAF1KDRBRAFRETABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060241149-A1 | Chemical compounds | ADAMS JERRY L | 2006-10-26 | — | — | US | disclosed |
| EP-1581514-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004043379-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241149-A1 | Chemical compounds | CHKB, MAP3K20, MAP3K6 | RAF1 205/4885KDR 2025/4885BRAF 191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.