Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.61 |
| ▸ | BRAF | P15056 | 3/20 | 0.54 |
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 3/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.51 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.49 |
| ▸ | RET | P07949 | 3/20 | 0.49 |
| ▸ | LCK | P06239 | 3/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.49 |
| ▸ | PLK4 | O00444 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | FYN | P06241 | 2/20 | 0.49 |
| ▸ | LYN | P07948 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14793075 | 0.89 | KDR (0.70) | KDRBRAFHTR2CHTR2AHTR2B | |
| SCHEMBL6071951 | 0.87 | KDR (0.67) | KDRBRAFHTR2CHTR2AHTR2B | |
| SCHEMBL6072374 | 0.87 | KDR (0.58) | KDRBRAFMAPK14RETLCK | |
| SCHEMBL6072502 | 0.84 | RAF1 (0.69) | KDRBRAFHTR2CHTR2AHTR2B | |
| SCHEMBL6071911 | 0.83 | RAF1 (0.57) | KDRBRAFHTR2CHTR2AHTR2B | |
| SCHEMBL14793110 | 0.83 | KDR (0.69) | KDRBRAFHTR2CHTR2AHTR2B | |
| SCHEMBL6071976 | 0.83 | KDR (0.62) | KDRBRAFHTR2CHTR2AHTR2B | |
| SCHEMBL14793062 | 0.83 | KDR (0.61) | KDRHTR2CHTR2BMAPK14RET | |
| SCHEMBL14793072 | 0.82 | KDR (0.61) | KDRBRAFHTR2CHTR2AHTR2B | |
| SCHEMBL6071927 | 0.82 | KDR (0.52) | KDRBRAFMAPK14NFKB1NR2C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060241149-A1 | Chemical compounds | ADAMS JERRY L | 2006-10-26 | — | — | US | disclosed |
| EP-1581514-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004043379-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241149-A1 | Chemical compounds | CHKB, MAP3K20, MAP3K6 | KDR 2025/4885BRAF 191/4885GRM5 2820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.