Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.53 |
| ▸ | RELA | Q04206 | 4/20 | 0.53 |
| ▸ | NR2C2 | P49116 | 3/20 | 0.53 |
| ▸ | TAB1 | Q15750 | 3/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 4/20 | 0.47 |
| ▸ | RAF1 | P04049 | 3/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14793062 | 0.87 | KDR (0.61) | KDRNFKB1NFKB2RELANR2C2 | |
| SCHEMBL6072483 | 0.87 | KDR (0.61) | KDRNFKB1NFKB2RELANR2C2 | |
| SCHEMBL14793110 | 0.85 | KDR (0.69) | KDRNFKB1NFKB2RELANR2C2 | |
| SCHEMBL6071976 | 0.85 | KDR (0.62) | KDRNFKB1NFKB2RELANR2C2 | |
| SCHEMBL6072488 | 0.85 | NFKB1 (0.49) | KDRNFKB1NFKB2RELANR2C2 | |
| SCHEMBL14793075 | 0.85 | KDR (0.70) | KDRNFKB1NFKB2RELANR2C2 | |
| SCHEMBL14793072 | 0.85 | KDR (0.61) | KDRNFKB1NFKB2RELANR2C2 | |
| SCHEMBL6071951 | 0.84 | KDR (0.67) | KDRMAPK14METBRAFRAF1 | |
| SCHEMBL6071911 | 0.84 | RAF1 (0.57) | KDRMAPK14METBRAFRAF1 | |
| SCHEMBL6072502 | 0.83 | RAF1 (0.69) | KDRMAPK14METBRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060241149-A1 | Chemical compounds | ADAMS JERRY L | 2006-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241149-A1 | Chemical compounds | CHKB, MAP3K20, MAP3K6 | KDR 2025/4885NFKB1 858/4885NFKB2 748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.