Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 2/20 | 0.36 |
| ▸ | PDE6A | P16499 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6073650 | 0.92 | PDE5A (0.38) | GRIN1GRIN2BPDE5APDE6A | |
| SCHEMBL6073625 | 0.85 | MEN1 (0.37) | GRIN1GRIN2BHSD17B10PDE5AALDH1A1 | |
| SCHEMBL20703796 | 0.84 | PDE4D (0.41) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL30635481 | 0.76 | HSD17B10 (0.50) | ADORA2AADORA2BHSD17B10ALDH1A1AURKA | |
| SCHEMBL8251682 | 0.75 | PDE5A (0.43) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL31008703 | 0.74 | GRIN1 (0.58) | GRIN1GRIN2B | |
| SCHEMBL20134012 | 0.74 | GRIN1 (0.58) | GRIN1GRIN2B | |
| SCHEMBL20704356 | 0.72 | PDE4D (0.42) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL15999458 | 0.72 | PDE4A (0.44) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6073328 | 0.71 | PDE5A (0.62) | PDE5APDE6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006126081-A2 | PYRIDINO [2 , 3-B] PYRAZINONES AS PDE-5 INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-11-30 | — | — | WO | disclosed |
| WO-2006126081-A2 | PYRIDINO [2 , 3-B] PYRAZINONES AS PDE-5 INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-11-30 | — | — | WO | disclosed |