Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.38 |
| ▸ | PDE6A | P16499 | 16/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6073334 | 0.92 | ADORA2A (0.39) | PDE5APDE6AGRIN1GRIN2B | |
| SCHEMBL20703796 | 0.85 | PDE4D (0.41) | PDE6AGRIN1GRIN2B | |
| SCHEMBL6073625 | 0.84 | MEN1 (0.37) | PDE5AGRIN1GRIN2B | |
| SCHEMBL6073328 | 0.79 | PDE5A (0.62) | PDE5APDE6A | |
| SCHEMBL30635481 | 0.75 | HSD17B10 (0.50) | — | |
| SCHEMBL1971615 | 0.75 | GRIA1 (0.45) | PDE5APDE6AGRIN1GRIN2BKCNH2 | |
| SCHEMBL20704356 | 0.74 | PDE4D (0.42) | PDE6AGRIN1GRIN2B | |
| SCHEMBL31008703 | 0.74 | GRIN1 (0.58) | GRIN1GRIN2B | |
| SCHEMBL20134012 | 0.74 | GRIN1 (0.58) | GRIN1GRIN2B | |
| SCHEMBL20704210 | 0.72 | PDE4D (0.48) | PDE6AGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006126081-A2 | PYRIDINO [2 , 3-B] PYRAZINONES AS PDE-5 INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-11-30 | — | — | WO | disclosed |
| WO-2006126081-A2 | PYRIDINO [2 , 3-B] PYRAZINONES AS PDE-5 INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-11-30 | — | — | WO | disclosed |