Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.53 |
| ▸ | DRD3 | P35462 | 4/20 | 0.53 |
| ▸ | DRD4 | P21917 | 3/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5642972 | 0.78 | KMT2A (0.57) | OPRM1DRD3DRD4DRD2KCNN4 | |
| SCHEMBL10814384 | 0.78 | OPRM1 (0.53) | OPRM1DRD3DRD4DRD2KCNN4 | |
| SCHEMBL375036 | 0.78 | OPRM1 (0.53) | OPRM1DRD3DRD4DRD2KCNN4 | |
| SCHEMBL16158180 | 0.77 | OPRM1 (0.51) | OPRM1DRD3DRD4DRD2KCNN4 | |
| SCHEMBL6073374 | 0.77 | CYP1A2 (0.59) | OPRM1DRD3DRD4DRD2KCNN4 | |
| SCHEMBL11536202 | 0.76 | KMT2A (0.48) | OPRM1DRD3DRD4KCNN4KMT2A | |
| SCHEMBL10814377 | 0.75 | OPRM1 (0.50) | OPRM1DRD3DRD4DRD2KCNN4 | |
| SCHEMBL31308059 | 0.75 | OPRM1 (0.46) | OPRM1DRD3DRD4DRD2KCNN4 | |
| SCHEMBL11884455 | 0.75 | MAPT (0.46) | KCNN4KMT2AMAPTCYP2C19CYP3A4 | |
| SCHEMBL1414646 | 0.74 | CYP1A2 (0.48) | KCNN4KMT2AMAPTCYP2C19HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006136823-A1 | HETEROCYCLIC CONTAINING AMINES AS KINASE B INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2006-12-28 | — | — | WO | disclosed |