Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.53 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.53 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | CASP6 | P55212 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MPI | P34949 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.50 |
| ▸ | NSD2 | O96028 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | G6PD | P11413 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6073350 | 1.00 | POLB (0.53) | POLBEIF4HAMY1AMEN1KMT2A | |
| SCHEMBL17548947 | 0.80 | MAPT (0.46) | POLBEIF4HAMY1AMEN1KMT2A | |
| SCHEMBL6073638 | 0.79 | POLB (0.72) | POLBMEN1KMT2AMAPTGAA | |
| SCHEMBL28420537 | 0.79 | POLB (0.56) | POLBEIF4HAMY1AMEN1KMT2A | |
| SCHEMBL6073641 | 0.79 | POLB (0.72) | POLBMEN1KMT2AMAPTGAA | |
| SCHEMBL2319124 | 0.79 | POLB (0.56) | POLBEIF4HAMY1AMEN1KMT2A | |
| SCHEMBL17927362 | 0.79 | POLB (0.72) | POLBMEN1KMT2AMAPTGAA | |
| SCHEMBL13268837 | 0.76 | ALOX12 (0.42) | POLBEIF4HAMY1AKMT2AMAPT | |
| SCHEMBL11410155 | 0.74 | MAOB (0.59) | POLBEIF4HAMY1AMEN1KMT2A | |
| SCHEMBL11410159 | 0.74 | MAOB (0.59) | POLBEIF4HAMY1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006135763-A2 | INHIBITORS OF DNA REPAIR ENZYMES AND METHODS OF USE THEREOF | THE JOHNS HOPKINS UNIVERSITY (US) | 2006-12-21 | — | — | WO | disclosed |