Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.60 |
| ▸ | EDNRA | P25101 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1857055 | 0.90 | KMT2A (0.59) | CASP6EDNRAKMT2ATTRRXFP1 | |
| Hydrochloric Acid SCHEMBL8861874 | 0.89 | KMT2A (0.57) | CASP6EDNRAKMT2ARXFP1MEN1 | |
| SCHEMBL4115318 | 0.89 | KMT2A (0.57) | CASP6EDNRAKMT2ATTRRXFP1 | |
| SCHEMBL15461567 | 0.87 | EDNRA (0.54) | CASP6EDNRAKMT2ARXFP1MEN1 | |
| SCHEMBL10902168 | 0.86 | TTR (0.53) | CASP6KMT2ATTRMEN1KDM4E | |
| SCHEMBL12994192 | 0.85 | TTR (0.49) | CASP6EDNRAKMT2ATTRALDH1A1 | |
| SCHEMBL3529089 | 0.85 | EDNRA (0.53) | CASP6EDNRAKMT2ARXFP1MEN1 | |
| SCHEMBL11441738 | 0.84 | ALDH1A1 (0.47) | CASP6EDNRATTRALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL8054311 | 0.84 | CDK2 (0.53) | CASP6EDNRAKMT2ARXFP1MEN1 | |
| SCHEMBL21878720 | 0.84 | EDNRA (0.52) | CASP6EDNRAKMT2ARXFP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2471363-A1 | Use of aryl-, heteroaryl- and benzylsulfonamide carboxylic acids, -carboxylic acid esters, -carboxylic acid amides and -carbonitriles and/or its salts for increasing stress tolerance in plants | Bayer CropScience AG (DE) | 2012-07-04 | — | — | EP | disclosed |
| US-7026475-B2 | Positive allosteric AMPA receptor modulators (PAARM), processes for preparing them, and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2006-04-11 | — | — | US | disclosed |
| US-20040122003-A1 | Positive allosteric AMPA receptor modulators (PAARM), processes for preparing them, and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2004-06-24 | — | — | US | disclosed |
| US-20040116412-A1 | Positive allosteric AMPA receptor modulators (PAARM), processes for preparing them, and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2004-06-17 | — | — | US | disclosed |
| EP-1404340-A1 | NAPHTOTHIAZINE POSITIVE ALLOSTERIC AMPA RECEPTOR MODULATORS (PAARM) | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2004-04-07 | — | — | EP | disclosed |
| US-20030100552-A1 | Positive allosteric AMPA receptor modulators (PAARM), processes for preparing them, and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-05-29 | — | — | US | disclosed |
| WO-2002100411-A1 | NAPHTOTHIAZINE POSITIVE ALLOSTERIC AMPA RECEPTOR MODULATORS (PAARM) | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2002-12-19 | — | — | WO | disclosed |
| EP-0558258-B1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-05-07 | — | — | EP | disclosed |
| US-5378715-A | Sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 1995-01-03 | — | — | US | disclosed |
| EP-0558258-A1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | E.R. SQUIBB & SONS, INC. (US) | 1993-09-01 | — | — | EP | disclosed |
| US-4749523-A | NEUTRALIZING ACID AND SUBSEQUENT AMINE ACYLATION TO AMIDE GROUP; EFFICIENT | HOECHST CELANESE CORPORATION (US) | 1988-06-07 | — | — | US | disclosed |
| EP-0168680-B1 | SOLID PHASE ACYLATION OF AMINOSULFONIC ACIDS | HOECHST CELANESE CORPORATION (US) | 1988-03-09 | — | — | EP | disclosed |
| EP-0168680-A1 | Solid phase acylation of aminosulfonic acids | HOECHST CELANESE CORPORATION (US) | 1986-01-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030100552-A1 | Positive allosteric AMPA receptor modulators (PAARM), processes for preparing them, and their use as pharmaceutical compositions | GRM1, GRM2, GRIN1 | CASP6 4875/4885EDNRA 389/4885KMT2A 1246/4885 |
| US-20040122003-A1 | Positive allosteric AMPA receptor modulators (PAARM), processes for preparing them, and their use as pharmaceutical compositions | GRM1, GRM2, GRIN1 | CASP6 4875/4885EDNRA 389/4885KMT2A 1246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.