Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.52 |
| ▸ | RELA | Q04206 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20588812 | 0.86 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2NFKB1NFKB2RELA | |
| SCHEMBL21853653 | 0.85 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2NFKB1NFKB2RELA | |
| SCHEMBL29546526 | 0.84 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2RAB9ANPC1NFKB1 | |
| SCHEMBL256224 | 0.84 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2RAB9ANPC1NFKB1 | |
| SCHEMBL6073963 | 0.82 | KDM4E (0.48) | ALDH1A1SMN1; SMN2RAB9ANPC1NFKB1 | |
| SCHEMBL20589650 | 0.78 | MEN1 (0.48) | ALDH1A1SMN1; SMN2NFKB1NFKB2RELA | |
| SCHEMBL423187 | 0.76 | MEN1 (0.64) | ALDH1A1SMN1; SMN2RAB9ANPC1NFKB1 | |
| SCHEMBL29897636 | 0.76 | MEN1 (0.64) | ALDH1A1SMN1; SMN2RAB9ANPC1NFKB1 | |
| SCHEMBL8397035 | 0.74 | MEN1 (0.62) | ALDH1A1SMN1; SMN2RAB9ANPC1NFKB1 | |
| SCHEMBL14799238 | 0.74 | ALDH1A1 (0.72) | ALDH1A1SMN1; SMN2RAB9ANPC1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053070-B2 | Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2006-05-30 | — | — | US | disclosed |
| US-20030073668-A1 | Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors | BOOTH RICHARD JOHN (US) | 2003-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073668-A1 | Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors | CDK9, CDK19, CDK3 | ALDH1A1 4111/4885SMN1; SMN2 3957/4885RAB9A 1460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.