Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.37 |
| ▸ | PDE4A | P27815 | 7/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.37 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | ATR | Q13535 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6708191 | 0.81 | MAPT (0.41) | ALDH1A1LMNAHTTSMN1; SMN2CHEK1 | |
| SCHEMBL1929068 | 0.79 | IKBKB (0.49) | KAT2BBAZ2BCHEK1 | |
| SCHEMBL1928617 | 0.79 | IKBKB (0.49) | KAT2BBAZ2BCHEK1 | |
| SCHEMBL1928622 | 0.79 | IKBKB (0.49) | KAT2BBAZ2BCHEK1 | |
| SCHEMBL3441348 | 0.71 | KAT2B (0.58) | KAT2BBAZ2BPDE4DPDE4APDE4B | |
| SCHEMBL1811110 | 0.67 | KAT2B (0.63) | KAT2BBAZ2BPDE4DPDE4APDE4B | |
| SCHEMBL1811109 | 0.67 | KAT2B (0.63) | KAT2BBAZ2BPDE4DPDE4APDE4B | |
| SCHEMBL2354093 | 0.66 | PDE4D (0.48) | KAT2BBAZ2BPDE4DPDE4APDE4B | |
| SCHEMBL2354086 | 0.66 | PDE4D (0.48) | KAT2BBAZ2BPDE4DPDE4APDE4B | |
| SCHEMBL6818987 | 0.65 | NPC1 (0.47) | PDE4DPDE4APDE4BPDE4CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7125896-B2 | Thiophene carboxamide compounds as inhibitors of enzyme IKK-2 | ASTRAZENECA AB (SE) | 2006-10-24 | — | — | US | disclosed |