Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4747449 | 0.86 | TSHR (0.54) | MEN1KMT2ACHEK1ALDH1A1MAPT | |
| SCHEMBL4221398 | 0.86 | TSHR (0.54) | MEN1KMT2ACHEK1ALDH1A1MAPT | |
| SCHEMBL4216723 | 0.84 | CCR1 (0.45) | MEN1KMT2ACHEK1ALDH1A1NPSR1 | |
| SCHEMBL4634082 | 0.84 | CCR1 (0.45) | MEN1KMT2ACHEK1ALDH1A1NPSR1 | |
| SCHEMBL1951762 | 0.77 | TSHR (0.46) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL3222025 | 0.77 | TSHR (0.46) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL13390934 | 0.76 | KMT2A (0.68) | MEN1KMT2AALDH1A1MAPTNPSR1 | |
| SCHEMBL13229845 | 0.75 | LMNA (0.46) | MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL4216032 | 0.75 | MAPT (0.51) | KMT2ACHEK1MAPTLMNATSHR | |
| SCHEMBL10889212 | 0.74 | ALDH1A1 (0.46) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005439-B2 | Compounds | ASTRAZENECA AB (SE) | 2006-02-28 | — | — | US | disclosed |
| US-20050239801-A1 | Novel compounds | ASTRAZENECA AB (SE) | 2005-10-27 | — | — | US | disclosed |
| EP-1299356-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-11 | — | — | EP | disclosed |
| US-20030153555-A1 | Novel compounds | ASTRAZENECA AB (SE) | 2003-08-14 | — | — | US | disclosed |
| EP-1299356-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2003-04-09 | — | — | EP | disclosed |
| WO-2001098272-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153555-A1 | Novel compounds | RPS4Y1, RPS4X, UGT2B7 | MEN1 272/4885KMT2A 2861/4885CHEK1 4506/4885 |
| US-20050239801-A1 | Novel compounds | CHRM2, CHRM1, C1R | MEN1 76/4885KMT2A 1836/4885CHEK1 4680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.