Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 7/20 | 0.44 |
| ▸ | LATS1 | O95835 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6075727 | 0.91 | CRHR1 (0.39) | CRHR1CNR1LATS1ACHEBCHE | |
| SCHEMBL6075724 | 0.91 | CRHR1 (0.39) | CRHR1CNR1LATS1ACHEBCHE | |
| SCHEMBL6075527 | 0.83 | ACP1 (0.45) | LATS1BCHE | |
| SCHEMBL6075668 | 0.81 | ADORA1 (0.46) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6076612 | 0.81 | ACHE (0.46) | CRHR1MAOAMAOBACHEBCHE | |
| SCHEMBL5733419 | 0.80 | ACP1 (0.45) | LATS1 | |
| SCHEMBL6075854 | 0.79 | PDE5A (0.40) | LATS1ACHEBCHERIPK1 | |
| SCHEMBL6075498 | 0.79 | PDE5A (0.41) | LATS1NPC1RAB9A | |
| SCHEMBL5732643 | 0.79 | IGF1R (0.47) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5732894 | 0.78 | IGF1R (0.42) | LATS1ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045526-B2 | Substituted 4-amino-2-aryl-tetrahydroquinazolines, their preparation, their use and pharmaceutical preparations comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-05-16 | — | — | US | claimed |