Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.47 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CCR4 | P51679 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6076060 | 0.99 | KDM4E (0.51) | HPGDKDM4EALDH1A1LMNACYP1A2 | |
| SCHEMBL5733788 | 0.98 | HPGD (0.50) | HPGDKDM4EALDH1A1LMNACYP1A2 | |
| SCHEMBL5733203 | 0.97 | KDM4E (0.51) | HPGDKDM4EALDH1A1LMNACYP1A2 | |
| SCHEMBL6075981 | 0.90 | FYN (0.46) | HPGDKDM4EALDH1A1LMNACYP1A2 | |
| SCHEMBL6075985 | 0.90 | FYN (0.46) | HPGDKDM4EALDH1A1LMNACYP1A2 | |
| SCHEMBL6075443 | 0.85 | HRH2 (0.47) | ALDH1A1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5733352 | 0.84 | ADORA3 (0.45) | KDM4EALDH1A1LMNAMAPTALOX5 | |
| SCHEMBL5732453 | 0.82 | ADORA3 (0.46) | KDM4EALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL6076928 | 0.82 | PDE5A (0.46) | HPGDKDM4EALDH1A1MAPTALOX5 | |
| SCHEMBL6075498 | 0.81 | PDE5A (0.41) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045526-B2 | Substituted 4-amino-2-aryl-tetrahydroquinazolines, their preparation, their use and pharmaceutical preparations comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-05-16 | — | — | US | claimed |