Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27636089 | 0.90 | EPHX2 (0.55) | TP53RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL6076341 | 0.87 | TP53 (0.50) | TP53RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL6077226 | 0.86 | ALDH1A1 (0.49) | TP53CYP3A4CYP2C19L3MBTL1RAB9A | |
| SCHEMBL6077185 | 0.84 | TP53 (0.45) | TP53RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL6076689 | 0.81 | TP53 (0.43) | TP53RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL18134844 | 0.81 | CYP3A4 (0.46) | CYP3A4CYP2C19L3MBTL1ALDH1A1HPGD | |
| SCHEMBL6077144 | 0.81 | TP53 (0.42) | TP53RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL6077139 | 0.81 | TP53 (0.48) | TP53L3MBTL1RAB9ANPC1ALDH1A1 | |
| SCHEMBL24667463 | 0.80 | ALDH1A1 (0.69) | TP53RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL6077041 | 0.80 | HPGD (0.51) | TP53CYP3A4CYP2C19RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101279927-A | Arylene-carboxylic acid (2-amino-phenyl)-amide derivatives as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 2008-10-08 | — | — | CN | claimed |
| CN-1723192-A | Arylene-carboxylic acid (2-amino-phenyl) -amide derivatives as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 2006-01-18 | — | — | CN | claimed |
| EP-1572625-A1 | ARYLENE-CARBOXYLIC ACID (2-AMINO-PHENYL)-AMIDE DERIVATIVES AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-14 | — | — | EP | claimed |
| US-20040138270-A1 | Novel arylene-carboxylic acid (2-amino-phenyl)-amide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-15 | — | — | US | claimed |
| WO-2004052838-A1 | ARYLENE-CARBOXYLIC ACID (2-AMINO-PHENYL)-AMIDE DERIVATIVES AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-24 | — | — | WO | claimed |
| CN-101279927-A | Arylene-carboxylic acid (2-amino-phenyl)-amide derivatives as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 2008-10-08 | — | — | CN | disclosed |
| US-7098247-B2 | Arylene-carboxylic acid (2-amino-phenyl)-amide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-08-29 | — | — | US | disclosed |
| CN-1723192-A | Arylene-carboxylic acid (2-amino-phenyl) -amide derivatives as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 2006-01-18 | — | — | CN | disclosed |
| EP-1572625-A1 | ARYLENE-CARBOXYLIC ACID (2-AMINO-PHENYL)-AMIDE DERIVATIVES AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-14 | — | — | EP | disclosed |
| US-20040138270-A1 | Novel arylene-carboxylic acid (2-amino-phenyl)-amide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-15 | — | — | US | disclosed |
| WO-2004052838-A1 | ARYLENE-CARBOXYLIC ACID (2-AMINO-PHENYL)-AMIDE DERIVATIVES AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138270-A1 | Novel arylene-carboxylic acid (2-amino-phenyl)-amide derivatives | MKI67, API5, ACIN1 | TP53 107/4885CYP3A4 394/4885CYP2C19 171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.