Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 4/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | AGER | Q15109 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 4/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6078413 | 0.87 | EPHX2 (0.57) | MAP2K1CA9CA1CA2AGER | |
| SCHEMBL6078620 | 0.84 | KMT2A (0.55) | MAP2K1CA9AGERARKMT2A | |
| SCHEMBL6077814 | 0.83 | CA9 (0.56) | MAP2K1CA9CA12CA1CA2 | |
| SCHEMBL6076379 | 0.81 | MAP2K1 (0.53) | MAP2K1CA9CA12ARKMT2A | |
| SCHEMBL6076371 | 0.80 | CA9 (0.55) | MAP2K1CA9CA12CA1KDR | |
| SCHEMBL6081603 | 0.78 | MAP2K1 (0.61) | MAP2K1CA9CA12ARKMT2A | |
| SCHEMBL6077260 | 0.77 | CA9 (0.61) | MAP2K1CA9ARKMT2A | |
| SCHEMBL13556629 | 0.76 | RAF1 (0.72) | MAP2K1CA9CA1CA2RAF1 | |
| SCHEMBL6078541 | 0.74 | KMT2A (0.51) | MAP2K1CA9KDRKMT2A | |
| SCHEMBL6082296 | 0.74 | MAP2K1 (0.56) | MAP2K1CA9CA12ARKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7074933-B2 | Urea and thiourea derivatives | WARNER LAMBERT COMPANY LLC (US) | 2006-07-11 | — | — | US | claimed |
| EP-1603882-A2 | UREA AND THIOUREA DERIVATIVES | Warner-Lambert Company LLC (US) | 2005-12-14 | — | — | EP | claimed |
| WO-2004072044-A2 | UREA AND THIOUREA DERIVATIVES | WARNER-LAMBERT COMPANY LLC (US) | 2004-08-26 | — | — | WO | claimed |
| US-7074933-B2 | Urea and thiourea derivatives | WARNER LAMBERT COMPANY LLC (US) | 2006-07-11 | — | — | US | disclosed |
| US-20040266820-A1 | Urea and thiourea derivatives | DU DANIEL Y (US) | 2004-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266820-A1 | Urea and thiourea derivatives | SHBG, ZP1, ZYX | MAP2K1 3471/4885CA9 1294/4885CA12 1754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.