Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.57 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | AGER | Q15109 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6077634 | 0.87 | MAP2K1 (0.51) | MAP2K1ARCA9KMT2AAGER | |
| SCHEMBL6078620 | 0.86 | KMT2A (0.55) | MAP2K1ARCA9KMT2AMEN1 | |
| SCHEMBL6077814 | 0.85 | CA9 (0.56) | EPHX2MAP2K1ARCA9KMT2A | |
| SCHEMBL6076371 | 0.81 | CA9 (0.55) | MAP2K1ARCA9P2RY1KMT2A | |
| SCHEMBL6081603 | 0.79 | MAP2K1 (0.61) | MAP2K1ARCA9KMT2AMEN1 | |
| SCHEMBL6077260 | 0.79 | CA9 (0.61) | MAP2K1ARCA9KMT2AMEN1 | |
| SCHEMBL6082296 | 0.76 | MAP2K1 (0.56) | MAP2K1ARCA9KMT2AMEN1 | |
| SCHEMBL11555827 | 0.75 | EPHX2 (1.00) | EPHX2KMT2AMEN1TP53MAPT | |
| SCHEMBL6076379 | 0.75 | MAP2K1 (0.53) | MAP2K1ARCA9KMT2AMEN1 | |
| SCHEMBL6078589 | 0.75 | MAP2K1 (0.53) | MAP2K1ARCA9KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7074933-B2 | Urea and thiourea derivatives | WARNER LAMBERT COMPANY LLC (US) | 2006-07-11 | — | — | US | claimed |
| EP-1603882-A2 | UREA AND THIOUREA DERIVATIVES | Warner-Lambert Company LLC (US) | 2005-12-14 | — | — | EP | claimed |
| WO-2004072044-A2 | UREA AND THIOUREA DERIVATIVES | WARNER-LAMBERT COMPANY LLC (US) | 2004-08-26 | — | — | WO | claimed |
| US-7074933-B2 | Urea and thiourea derivatives | WARNER LAMBERT COMPANY LLC (US) | 2006-07-11 | — | — | US | disclosed |
| US-20040266820-A1 | Urea and thiourea derivatives | DU DANIEL Y (US) | 2004-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266820-A1 | Urea and thiourea derivatives | SHBG, ZP1, ZYX | EPHX2 2337/4885MAP2K1 3471/4885AR 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.