Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 11/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | F12 | P00748 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | FAP | Q12884 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | Q9HBH1 | 1/20 | 0.37 | |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6077392 | 0.90 | F2 (0.61) | F2F12F10PRSS1PRSS2 | |
| SCHEMBL6079772 | 0.87 | F2 (0.50) | F2P2RX7F12ALDH1A1KCNH2 | |
| SCHEMBL6078507 | 0.84 | P2RX7 (0.43) | F2P2RX7ALDH1A1F10PRSS1 | |
| SCHEMBL6077615 | 0.79 | F2 (0.60) | F2F12ALDH1A1F10PRSS1 | |
| SCHEMBL6077730 | 0.79 | F2 (0.39) | F2DPP4ALDH1A1F10PRSS1 | |
| SCHEMBL6919688 | 0.79 | F2 (0.52) | F2DPP4F10PRSS1PRSS3 | |
| SCHEMBL6078134 | 0.79 | F2 (0.78) | F2F12F10PRSS1PRSS2 | |
| SCHEMBL6922167 | 0.78 | F2 (0.52) | F2F12DPP4F10PRSS1 | |
| SCHEMBL6078258 | 0.77 | F2 (0.57) | F2F12ALDH1A1F10PRSS1 | |
| Hydrochloric Acid SCHEMBL6079164 | 0.77 | F2 (0.75) | F2DPP4FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144899-B2 | Thrombin inhibitors | MERCK & CO., INC. (US) | 2006-12-05 | — | — | US | disclosed |
| US-20040073025-A1 | Thrombin inhibitors | MERCK SHARP & DOHME CORP. | 2004-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040073025-A1 | Thrombin inhibitors | F2, F11, F10 | F2 1/4885P2RX7 1957/4885F12 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.