Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6078138 | 0.88 | AAK1 (0.33) | AAK1CACNA1B | |
| SCHEMBL6078328 | 0.86 | AAK1 (0.34) | AAK1CACNA1BTP53SMN1; SMN2 | |
| SCHEMBL6078006 | 0.84 | EPHX1 (0.34) | — | |
| SCHEMBL6924571 | 0.76 | TP53 (0.34) | AAK1CACNA1BTP53SMN1; SMN2 | |
| SCHEMBL6924852 | 0.75 | AAK1 (0.33) | AAK1CACNA1BSMN1; SMN2 | |
| SCHEMBL6077898 | 0.74 | F2 (0.51) | — | |
| SCHEMBL6925791 | 0.74 | F2 (0.40) | — | |
| SCHEMBL6078119 | 0.70 | EPHX1 (0.34) | — | |
| Hydrochloric Acid SCHEMBL6077897 | 0.70 | EPHX1 (0.33) | — | |
| SCHEMBL6923429 | 0.69 | F2 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144899-B2 | Thrombin inhibitors | MERCK & CO., INC. (US) | 2006-12-05 | — | — | US | disclosed |
| US-20040073025-A1 | Thrombin inhibitors | MERCK SHARP & DOHME CORP. | 2004-04-15 | — | — | US | disclosed |
| WO-2002064559-A2 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040073025-A1 | Thrombin inhibitors | F2, F11, F10 | AAK1 3658/4885CACNA1B 2627/4885TP53 4739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.