Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.53 |
| ▸ | CMA1 | P23946 | 16/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | CTRC | Q99895 | 4/20 | 0.49 |
| ▸ | ACE | P12821 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6078441 | 0.83 | ACE (0.47) | F2CMA1ACE | |
| SCHEMBL6078290 | 0.82 | F2 (0.43) | F2CMA1PRSS1CTRC | |
| SCHEMBL7514001 | 0.81 | F2 (0.77) | F2 | |
| SCHEMBL6078122 | 0.81 | F2 (0.77) | F2 | |
| SCHEMBL7513991 | 0.81 | F2 (0.77) | F2 | |
| Hydrochloric Acid SCHEMBL6077067 | 0.81 | F2 (0.75) | F2 | |
| SCHEMBL7065318 | 0.78 | F2 (0.57) | F2CMA1PRSS1ACE | |
| SCHEMBL8770791 | 0.77 | F2 (0.62) | F2CMA1PRSS1CTRCACE | |
| SCHEMBL16576478 | 0.77 | F2 (0.65) | F2CMA1PRSS1CTRCACE | |
| SCHEMBL3692085 | 0.77 | ACE (0.77) | F2CMA1PRSS1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144899-B2 | Thrombin inhibitors | MERCK & CO., INC. (US) | 2006-12-05 | — | — | US | disclosed |
| US-20040073025-A1 | Thrombin inhibitors | MERCK SHARP & DOHME CORP. | 2004-04-15 | — | — | US | disclosed |
| WO-2002064559-A2 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040073025-A1 | Thrombin inhibitors | F2, F11, F10 | F2 1/4885CMA1 141/4885PRSS1 106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.