Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | CMA1 | P23946 | 9/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6078438 | 0.83 | F2 (0.53) | ACEF2CMA1 | |
| SCHEMBL6078292 | 0.81 | SCN9A (0.37) | ACESCN9ACMA1 | |
| SCHEMBL7513994 | 0.81 | F2 (0.60) | ACEF2 | |
| SCHEMBL6078129 | 0.81 | F2 (0.60) | ACEF2 | |
| Hydrochloric Acid SCHEMBL6077070 | 0.81 | F2 (0.59) | ACEF2 | |
| SCHEMBL7065314 | 0.76 | ACE (0.49) | ACEF2CMA1 | |
| SCHEMBL6077640 | 0.73 | F2 (0.48) | F2 | |
| Hydrochloric Acid SCHEMBL6078422 | 0.72 | F2 (0.60) | F2 | |
| Hydrochloric Acid SCHEMBL6077536 | 0.72 | F2 (0.60) | F2 | |
| SCHEMBL7352711 | 0.71 | ACE (0.53) | ACESCN9AF2CMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144899-B2 | Thrombin inhibitors | MERCK & CO., INC. (US) | 2006-12-05 | — | — | US | disclosed |
| US-20040073025-A1 | Thrombin inhibitors | MERCK SHARP & DOHME CORP. | 2004-04-15 | — | — | US | disclosed |
| WO-2002064559-A2 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040073025-A1 | Thrombin inhibitors | F2, F11, F10 | ACE 687/4885SCN9A 1729/4885F2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.