Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 10/20 | 0.44 |
| ▸ | F10 | P00742 | 7/20 | 0.44 |
| ▸ | F2 | P00734 | 7/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.36 |
| ▸ | F7 | P08709 | 3/20 | 0.35 |
| ▸ | TMPRSS15 | P98073 | 4/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6031605 | 1.00 | PRSS1 (0.44) | PRSS1F10F2KLKB1F7 | |
| Acetic Acid SCHEMBL6078037 | 0.98 | PRSS1 (0.43) | PRSS1F10F2KLKB1F7 | |
| SCHEMBL6028237 | 0.91 | F10 (0.36) | PRSS1F10F2PTGER3OPRK1 | |
| SCHEMBL6028232 | 0.91 | F10 (0.36) | PRSS1F10F2PTGER3OPRK1 | |
| Acetic Acid SCHEMBL6077133 | 0.89 | PRSS1 (0.43) | PRSS1F10F2F7TMPRSS15 | |
| Acetic Acid SCHEMBL6076965 | 0.89 | KLKB1 (0.35) | PRSS1F10F2KLKB1F7 | |
| Acetic Acid SCHEMBL6028097 | 0.86 | F10 (0.47) | PRSS1F10F2F7OPRK1 | |
| Acetic Acid SCHEMBL6078758 | 0.85 | F2 (0.42) | PRSS1F10F2KLKB1F7 | |
| SCHEMBL6029310 | 0.83 | OPRK1 (0.34) | KLKB1PTGER3OPRK1 | |
| SCHEMBL6029315 | 0.83 | OPRK1 (0.34) | KLKB1PTGER3OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7056932-B2 | Heterocyclyl substituted 1-alkoxy acetic acid amides | HOFFMAN-LA ROCHE INC. (US) | 2006-06-06 | — | — | US | disclosed |
| US-20050137168-A1 | Heterocyclyl substituted 1-alkoxy acetic acid amides | HOFFMANN-LA ROCHE INC. | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137168-A1 | Heterocyclyl substituted 1-alkoxy acetic acid amides | F12, TFPI, F11 | PRSS1 311/4885F10 8/4885F2 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.