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SCHEMBL6079356

SCHEMBL6079356

N=C(Nc1ccc2ccc(S(=O)(=O)Nc3ccc(Cl)c(C(=O)O)c3)cc2c1)Nc1ccc2ccc(S(=O)(=O)Nc3ccc(Cl)c(C(=O)O)c3)cc2c1

nearest known ligand 0.83

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 3/20 0.56
▸ KMT2A Q03164 3/20 0.56
▸ ALDH1A1 P00352 2/20 0.56
▸ TP53 P04637 1/20 0.49
▸ MIF P14174 1/20 0.47
▸ LMNA P02545 1/20 0.47
▸ GAA P10253 1/20 0.47
▸ L3MBTL1 Q9Y468 1/20 0.47
▸ HTT P42858 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6079248 0.91 MEN1 (0.58) MEN1KMT2AALDH1A1TP53
SCHEMBL6078214 0.89 MEN1 (0.57) MEN1KMT2AALDH1A1LMNAGAA
SCHEMBL6078676 0.88 LMNA (0.64) MEN1KMT2AALDH1A1LMNAGAA
SCHEMBL6079195 0.85 TP53 (0.60) MEN1KMT2AALDH1A1TP53
SCHEMBL6078640 0.85 MEN1 (0.57) MEN1KMT2AALDH1A1TP53LMNA
SCHEMBL6429403 0.84 LMNA (0.62) MEN1KMT2AALDH1A1LMNAGAA
SCHEMBL6078220 0.84 TP53 (0.58) MEN1KMT2AALDH1A1TP53
SCHEMBL6079328 0.83 KMT2A (0.56) MEN1KMT2AALDH1A1TP53MIF
SCHEMBL6077690 0.83 MEN1 (0.74) MEN1KMT2ATP53
SCHEMBL6078718 0.82 MEN1 (0.49) MEN1KMT2AALDH1A1TP53MIF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7071231-B2 Naphthalene ureas as glucose uptake enhancers TELIK, INC. (US) 2006-07-04 — — US disclosed
US-6458998-B1 NAPHTHALENEUREAS AS ANTIDIABETIC AGENTS TELIK, INC. 2002-10-01 — — US disclosed