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SCHEMBL6429403

SCHEMBL6429403

COC(=O)c1cc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(S(=O)(=O)Nc6ccc(Cl)c(C(=O)O)c6)cc5c4)cc3c2)ccc1Cl

nearest known ligand 0.85

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 3/20 0.62
▸ ALDH1A1 P00352 2/20 0.62
▸ GAA P10253 2/20 0.62
▸ L3MBTL1 Q9Y468 1/20 0.62
▸ KMT2A Q03164 5/20 0.58
▸ MEN1 O00255 4/20 0.58
▸ SMN1; SMN2 Q16637 1/20 0.58
▸ MAPT P10636 1/20 0.53
▸ HTT P42858 1/20 0.53
▸ NPSR1 Q6W5P4 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6078277 0.96 LMNA (0.67) LMNAALDH1A1GAAL3MBTL1KMT2A
SCHEMBL6079248 0.92 MEN1 (0.58) ALDH1A1KMT2AMEN1
SCHEMBL6445032 0.92 LMNA (0.55) LMNAALDH1A1GAAL3MBTL1KMT2A
SCHEMBL6079195 0.87 TP53 (0.60) ALDH1A1KMT2AMEN1
SCHEMBL6079143 0.87 ALDH1A1 (0.64) LMNAALDH1A1GAAL3MBTL1KMT2A
SCHEMBL6078676 0.87 LMNA (0.64) LMNAALDH1A1GAAL3MBTL1KMT2A
SCHEMBL6078214 0.87 MEN1 (0.57) LMNAALDH1A1GAAL3MBTL1KMT2A
SCHEMBL7966502 0.86 ALDH1A1 (0.67) ALDH1A1GAAKMT2AMEN1
SCHEMBL6079170 0.86 MEN1 (0.57) ALDH1A1KMT2AMEN1SMN1; SMN2MAPT
SCHEMBL6077690 0.84 MEN1 (0.74) KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1181271-B1 NAPHTHALENE UREAS AS GLUCOSE UPTAKE ENHANCERS TELIK INC (US) 2005-01-19 — — EP claimed