Sugi Predict

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SCHEMBL6079368

SCHEMBL6079368

O=C(O)c1cccc(NS(=O)(=O)c2ccc3ccc(NC(=S)Nc4ccc5ccc(S(=O)(=O)Nc6ccc(Cl)c(C(=O)O)c6)cc5c4)cc3c2)c1

nearest known ligand 0.71

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 5/20 0.71
▸ KMT2A Q03164 5/20 0.71
▸ AKR1C3 P42330 1/20 0.55
▸ CA1 P00915 1/20 0.54
▸ CA2 P00918 1/20 0.54
▸ TP53 P04637 1/20 0.53
▸ POLB P06746 1/20 0.51
▸ ALDH1A1 P00352 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6077690 0.92 MEN1 (0.74) MEN1KMT2AAKR1C3TP53POLB
SCHEMBL6078220 0.91 TP53 (0.58) MEN1KMT2ATP53ALDH1A1
SCHEMBL6079497 0.89 MEN1 (0.55) MEN1KMT2AALDH1A1
SCHEMBL6078719 0.89 MEN1 (0.55) MEN1KMT2ACA1CA2ALDH1A1
SCHEMBL6079206 0.86 MEN1 (0.51) MEN1KMT2ATP53ALDH1A1
SCHEMBL6079922 0.86 MAPT (0.60) MEN1KMT2AALDH1A1
SCHEMBL6078568 0.83 MEN1 (0.48) MEN1KMT2AALDH1A1
SCHEMBL6079248 0.83 MEN1 (0.58) MEN1KMT2ATP53ALDH1A1
SCHEMBL6079195 0.83 TP53 (0.60) MEN1KMT2ATP53ALDH1A1
SCHEMBL6078876 0.82 MEN1 (0.48) MEN1KMT2ACA1CA2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7071231-B2 Naphthalene ureas as glucose uptake enhancers TELIK, INC. (US) 2006-07-04 — — US disclosed
US-6458998-B1 NAPHTHALENEUREAS AS ANTIDIABETIC AGENTS TELIK, INC. 2002-10-01 — — US disclosed