Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | PLAU | P00749 | 3/20 | 0.53 |
| ▸ | TCF4 | P15884 | 2/20 | 0.53 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | PLAT | P00750 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6079143 | 0.92 | ALDH1A1 (0.64) | MAPTALDH1A1LMNAGAAL3MBTL1 | |
| SCHEMBL6078415 | 0.92 | ALDH1A1 (0.59) | MAPTALDH1A1LMNAGAAL3MBTL1 | |
| SCHEMBL6078679 | 0.91 | LMNA (0.56) | MAPTALDH1A1LMNAGAAL3MBTL1 | |
| SCHEMBL6079074 | 0.89 | LMNA (0.54) | MAPTALDH1A1LMNAGAAL3MBTL1 | |
| SCHEMBL6079183 | 0.86 | LMNA (0.53) | MAPTALDH1A1LMNAGAAL3MBTL1 | |
| SCHEMBL6079368 | 0.86 | MEN1 (0.71) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL6078277 | 0.84 | LMNA (0.67) | MAPTALDH1A1LMNAGAAL3MBTL1 | |
| SCHEMBL6079588 | 0.84 | LMNA (0.49) | MAPTALDH1A1LMNAGAAL3MBTL1 | |
| SCHEMBL6079082 | 0.83 | LMNA (0.48) | ALDH1A1LMNAGAAL3MBTL1KMT2A | |
| SCHEMBL6078558 | 0.83 | TCF4 (0.65) | MAPTLMNAPLAUTCF4CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071231-B2 | Naphthalene ureas as glucose uptake enhancers | TELIK, INC. (US) | 2006-07-04 | — | — | US | disclosed |
| US-6458998-B1 | NAPHTHALENEUREAS AS ANTIDIABETIC AGENTS | TELIK, INC. | 2002-10-01 | — | — | US | disclosed |