Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6079361 | 1.00 | LMNA (0.36) | LMNAALDH1A1GLACYP1A2CYP2C9 | |
| SCHEMBL6079017 | 0.89 | CACNA1G (0.31) | ALDH1A1GLACACNA1GCACNA1BCACNA1C | |
| SCHEMBL6079011 | 0.89 | CACNA1G (0.31) | ALDH1A1GLACACNA1GCACNA1BCACNA1C | |
| SCHEMBL6079148 | 0.85 | SLC6A4 (0.34) | ALDH1A1GLACACNA1GCACNA1BCACNA1C | |
| SCHEMBL6078728 | 0.82 | SLC6A4 (0.45) | CACNA1GCACNA1BCACNA1CPDK2SLC6A4 | |
| SCHEMBL6078732 | 0.82 | SLC6A4 (0.45) | CACNA1GCACNA1BCACNA1CPDK2SLC6A4 | |
| SCHEMBL6079517 | 0.76 | CACNA1G (0.33) | LMNAALDH1A1GLACYP1A2CYP2C9 | |
| SCHEMBL6078329 | 0.75 | LMNA (0.38) | LMNAALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6078323 | 0.75 | LMNA (0.38) | LMNAALDH1A1CYP1A2CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL6078597 | 0.74 | SLC6A4 (0.39) | LMNACYP1A2CYP2C9CYP2C19GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7119109-B2 | Heteroarylheteroalkylamine derivatives and their use as inhibitors of nitric oxide synthase | ASTRAZENECA AB (SE) | 2006-10-10 | — | — | US | disclosed |