Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6077882 | 0.95 | ALDH1A1 (0.77) | ALDH1A1MEN1KMT2APTPN5TSHR | |
| SCHEMBL6079099 | 0.91 | ALDH1A1 (0.58) | ALDH1A1MEN1KMT2AHSD17B10PRMT1 | |
| SCHEMBL7966502 | 0.88 | ALDH1A1 (0.67) | ALDH1A1MEN1KMT2APTPN5TSHR | |
| SCHEMBL6078851 | 0.86 | ALDH1A1 (0.62) | ALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL6079663 | 0.85 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2APRMT1 | |
| SCHEMBL6428822 | 0.84 | PRMT1 (0.56) | ALDH1A1PRMT1 | |
| SCHEMBL6078378 | 0.84 | PRMT1 (0.61) | ALDH1A1MEN1KMT2APTPN5PRMT1 | |
| SCHEMBL6079548 | 0.83 | ALDH1A1 (0.59) | ALDH1A1MEN1KMT2A | |
| SCHEMBL6078234 | 0.83 | PRMT1 (0.54) | ALDH1A1MEN1KMT2APRMT1 | |
| SCHEMBL6078356 | 0.82 | MEN1 (0.58) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071231-B2 | Naphthalene ureas as glucose uptake enhancers | TELIK, INC. (US) | 2006-07-04 | — | — | US | disclosed |
| EP-1181271-B1 | NAPHTHALENE UREAS AS GLUCOSE UPTAKE ENHANCERS | TELIK INC (US) | 2005-01-19 | — | — | EP | disclosed |
| US-6458998-B1 | NAPHTHALENEUREAS AS ANTIDIABETIC AGENTS | TELIK, INC. | 2002-10-01 | — | — | US | disclosed |