Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPD | P32754 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8220420 | 0.80 | HPD (0.67) | HPDMAPTMAPK1FLT1FLT4 | |
| Nitisinone SCHEMBL29372670 | 0.77 | HPD (1.00) | HPDMAPTMAPK1FLT1FLT4 | |
| Nitisinone SCHEMBL338795 | 0.77 | HPD (1.00) | HPDMAPTMAPK1FLT1FLT4 | |
| Nitisinone SCHEMBL15537279 | 0.77 | HPD (1.00) | HPDMAPTMAPK1FLT1FLT4 | |
| SCHEMBL442397 | 0.76 | HPD (0.60) | HPDMAPTFLT1FLT4KDR | |
| SCHEMBL5452045 | 0.76 | HPD (0.60) | HPDMAPTMAPK1FLT1FLT4 | |
| Hydrochloric Acid SCHEMBL11776053 | 0.75 | HPD (0.59) | HPDMAPTFLT1FLT4KDR | |
| Ammonia Solution, Strong SCHEMBL28953061 | 0.75 | HPD (0.59) | HPDMAPTFLT1FLT4KDR | |
| SCHEMBL18212599 | 0.72 | HPD (0.60) | HPDMAPTMAPK1FLT1FLT4 | |
| SCHEMBL2323726 | 0.72 | HPD (0.59) | HPDMAPTFLT1FLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210254056-A1 | IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS | CAMP4 THERAPEUTICS CORPORATION | 2021-08-19 | — | — | US | disclosed |
| US-9187762-B2 | Compositions and methods comprising sequences having hydroxyphenylpyruvate dioxygenase (HPPD) activity | PIONEER HI-BRED INTERNATIONAL, INC. (US) | 2015-11-17 | — | — | US | disclosed |
| EP-2603591-A1 | COMPOSITIONS AND METHODS COMPRISING SEQUENCES HAVING HYDROXYPHENYLPYRUVATE DIOXYGENASE (HPPD) ACTIVITY | Pioneer Hi-Bred International Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012021785-A1 | COMPOSITIONS AND METHODS COMPRISING SEQUENCES HAVING HYDROXYPHENYLPYRUVATE DIOXYGENASE (HPPD) ACTIVITY | PIONEER HI-BRED INTERNATIONAL, INC. (US) | 2012-02-16 | — | — | WO | disclosed |
| US-20120042413-A1 | Compositions And Methods Comprising Sequences Having Hydroxyphenylpyruvate Dioxygenase (HPPD) Activity | PIONEER HI-BRED INTERNATIONAL, INC. (US) | 2012-02-16 | — | — | US | disclosed |