Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 2/20 | 0.62 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.55 |
| ▸ | CTSG | P08311 | 2/20 | 0.55 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.55 |
| ▸ | CMA1 | P23946 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | ESRRG | P62508 | 1/20 | 0.49 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24224237 | 0.88 | PTPRC (0.57) | PTPRCPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL27453159 | 0.85 | PRSS1 (0.69) | PTPRCPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL14427898 | 0.85 | PRSS1 (0.51) | PTPRCPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL13605087 | 0.85 | PTPRC (0.57) | PTPRCRAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL834521 | 0.85 | PTPRC (0.57) | PTPRCKDM4ERAB9ANPC1ESRRG | |
| SCHEMBL12301492 | 0.85 | TDP1 (0.65) | PTPRCGAARAB9ANPC1LMNA | |
| SCHEMBL25366312 | 0.84 | PTPRC (0.57) | PTPRCPKMRAB9ANPC1GPR139 | |
| SCHEMBL3961994 | 0.84 | GAA (0.59) | PRSS1CTSGCTRB1CMA1GAA | |
| SCHEMBL6085598 | 0.83 | PTPRC (0.49) | PTPRCPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL30572070 | 0.83 | KMT2A (0.56) | PTPRCRAB9ANPC1SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101945852-A | Azetidine derivatives, their preparation and their use in therapy | SANOFI AVENTIS | 2011-01-12 | — | — | CN | claimed |
| CN-101945852-A | Azetidine derivatives, their preparation and their use in therapy | SANOFI AVENTIS | 2011-01-12 | — | — | CN | disclosed |
| CN-1688600-B | Template-fixed peptidomimetics with antibacterial activity | POLYPHOR LTD | 2010-04-28 | — | — | CN | disclosed |
| EP-1757582-A1 | ARYLALKYLAMINES AND PROCESS FOR PRODUCTION THEREOF | TANABE SEIYAKU CO., LTD. (JP) | 2007-02-28 | — | — | EP | disclosed |
| US-7015223-B1 | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade | PHARMACIA CORPORATION (US) | 2006-03-21 | — | — | US | disclosed |
| CN-1688600-A | Template-fixed peptidomimetics with antibacterial activity | POLYPHOR LTD (CH) | 2005-10-26 | — | — | CN | disclosed |
| US-6906068-B1 | Substituted polycyclic aryl and heteroaryl 1,2,4 - triazinones useful as anticoagulants | PHARMACIA CORPORATION (US) | 2005-06-14 | — | — | US | disclosed |
| US-20050054643-A1 | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade | PHARMACIA CORPORATION | 2005-03-10 | — | — | US | disclosed |
| EP-1458747-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS AS INHIBITORS OF SERINE PROTEASES | Polyphor Ltd. (CH) | 2004-09-22 | — | — | EP | disclosed |
| CN-1157380-C | Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants agents | �ź㴫 | 2004-07-14 | — | — | CN | disclosed |
| US-6750342-B1 | INHIBITORS OF SERINE PROTEASES; ANTICOAGULANT | PHARMACIA CORPORATION | 2004-06-15 | — | — | US | disclosed |
| US-6653316-B1 | Coronary artery and cerebrovascular diseases | PHARMACIA CORPORATION | 2003-11-25 | — | — | US | disclosed |
| WO-2003054000-A1 | TEMPLATE-FIXED PEPTIDOMIMETICSAS INHIBITORS OF SERINE PROTEASES | POLYPHOR LTD. (CH) | 2003-07-03 | — | — | WO | disclosed |
| CN-1351593-A | Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants agents | PHARMACIA CO (US) | 2002-05-29 | — | — | CN | disclosed |
| EP-1178970-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRYMIDINONES USEFUL AS ANTICOAGULANTS | Pharmacia Corporation (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2001087851-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRIMIDINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-11-22 | — | — | WO | disclosed |
| WO-2000069832-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRYMIDINONES USEFUL AS ANTICOAGULANTS | PHARMACIA CORPORATION (US) | 2000-11-23 | — | — | WO | disclosed |
| CN-1041919-C | N-(3-piperidinylcarbonyl)-beta-alanine derivatives as PAF antagonists | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-02-03 | — | — | CN | disclosed |
| CN-1116847-A | N- (3-piperidinylcarbonyl) -beta-aminopropionic acid derivatives as PAF antagonists | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-02-14 | — | — | CN | disclosed |
| US-5212158-A | Nootropic agents | INORGAN SA RECHERCHE & DEVELOPPEMENT PHARMACEUTIQUES, CAS (CH) | 1993-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054643-A1 | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade | TFPI, PLAT, SERPINC1 | PTPRC 1290/4885PRSS1 7/4885CTSG 278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.