Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6882197 | 0.86 | MAPT (0.52) | MAPTSMN1; SMN2HTTKMT2AALDH1A1 | |
| SCHEMBL6024619 | 0.86 | MAPT (0.52) | MAPTSMN1; SMN2HTTKMT2AALDH1A1 | |
| SCHEMBL4896553 | 0.86 | MAPT (0.52) | MAPTSMN1; SMN2HTTKMT2AALDH1A1 | |
| SCHEMBL10163173 | 0.84 | MAPT (0.54) | MAPTSMN1; SMN2HTTKMT2AALDH1A1 | |
| SCHEMBL27803980 | 0.81 | KMT2A (0.50) | MAPTSMN1; SMN2HTTKMT2AALDH1A1 | |
| SCHEMBL412018 | 0.81 | MAPT (0.50) | MAPTSMN1; SMN2HTTKMT2AALDH1A1 | |
| SCHEMBL239274 | 0.81 | MAPT (0.50) | MAPTSMN1; SMN2HTTKMT2AALDH1A1 | |
| SCHEMBL555036 | 0.81 | MAPT (0.50) | MAPTSMN1; SMN2HTTKMT2AALDH1A1 | |
| SCHEMBL5406733 | 0.81 | MAPT (0.51) | MAPTSMN1; SMN2HTTKMT2AALDH1A1 | |
| SCHEMBL5406742 | 0.81 | MAPT (0.51) | MAPTSMN1; SMN2HTTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117903033-A | Synthesis method of taxane side chain intermediate | 上海卓鼎生物技术有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-104356157-B | A kind of preparation method of chiral four-membered ring taxane side chain compound | 江苏红豆杉药业有限公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-106632297-A | Docetaxel side chain 2'-derived novel taxanes antitumor compound as well as synthesis method and application thereof | 吉林医药学院 | 2017-05-10 | — | — | CN | disclosed |
| CN-106632296-A | Novel taxane anti-tumor compound as well as synthesis method and application thereof | 吉林医药学院 | 2017-05-10 | — | — | CN | disclosed |
| CN-102010383-B | Method for preparing docetaxel chiral side chain intermediate | SHANGHAI BIOSUNDRUG SCIENCE & TECHNOLOGY CO LTD | 2012-08-15 | — | — | CN | disclosed |
| CN-102010383-A | Method for preparing docetaxel chiral side chain intermediate | SHANGHAI BLOSUNDRUG SCIENCE & TECHNOLOGY CO LTD | 2011-04-13 | — | — | CN | disclosed |
| CN-1310897-C | A semi-synthetic process for the preparation of N debenzoylpaclitaxel | INDENA SPA (IT) | 2007-04-18 | — | — | CN | disclosed |
| US-7053222-B2 | Semi-synthetic process for the preparation of N-debenzoylpaclitaxel | INDENA S.P.A. (IT) | 2006-05-30 | — | — | US | disclosed |
| EP-1495011-B1 | A SEMI-SYNTHETIC PROCESS FOR THE PREPARATION OF N DEBENZOYLPACLITAXEL | INDENA SPA (IT) | 2005-12-28 | — | — | EP | disclosed |
| CN-1646512-A | A semi-synthetic process for the preparation of N debenzoylpaclitaxel | INDENA SPA (IT) | 2005-07-27 | — | — | CN | disclosed |
| US-20050049297-A1 | Semi-synthetic process for the preparation of N-debenzoylpaclitaxel | INDENA S. P. A. (IT) | 2005-03-03 | — | — | US | disclosed |
| EP-1495011-A1 | A SEMI-SYNTHETIC PROCESS FOR THE PREPARATION OF N DEBENZOYLPACLITAXEL | INDENA S.p.A. (IT) | 2005-01-12 | — | — | EP | disclosed |
| US-20040005562-A9 | Comprises tranferase protein associated with biosynthesis of taxoids for treating breast and ovarian cancers | WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION | 2004-01-08 | — | — | US | disclosed |
| WO-2003087077-A1 | A SEMI-SYNTHETIC PROCESS FOR THE PREPARATION OF N DEBENZOYLPACLITAXEL | INDENA S.P.A. (IT) | 2003-10-23 | — | — | WO | disclosed |
| US-20030108891-A1 | Transacylases of the paclitaxel biosynthetic pathway | WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION | 2003-06-12 | — | — | US | disclosed |
| CN-1216039-A | Process for preparing taxol | UPJOHN CO (US) | 1999-05-05 | — | — | CN | disclosed |
| EP-0674630-A1 | 7-HALO- AND 7$g(b),8$g(b)-METHANO-TAXOLS, ANTINEOPLASTIC USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARMACIA & UPJOHN COMPANY (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994013655-A1 | 7-HALO- AND 7β,8β-METHANO-TAXOLS, ANTINEOPLASTIC USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | THE UPJOHN COMPANY (US) | 1994-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050049297-A1 | Semi-synthetic process for the preparation of N-debenzoylpaclitaxel | UGT2B7, UGT2B17, CYP3A7 | MAPT 1892/4885SMN1; SMN2 1596/4885HTT 3209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.