Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21552476 | 0.95 | LMNA (0.39) | LMNAL3MBTL1TDP1AKR1B1PDE4A | |
| SCHEMBL2559273 | 0.85 | LMNA (0.39) | LMNAL3MBTL1TDP1AKR1B1PDE4A | |
| SCHEMBL234252 | 0.81 | LMNA (0.36) | LMNAL3MBTL1TDP1AKR1B1PDE4A | |
| SCHEMBL4338288 | 0.81 | LMNA (0.36) | LMNAL3MBTL1TDP1AKR1B1PDE4A | |
| SCHEMBL2558960 | 0.81 | LMNA (0.36) | LMNAL3MBTL1TDP1AKR1B1PDE4A | |
| SCHEMBL3127123 | 0.80 | LMNA (0.42) | LMNAL3MBTL1TDP1AKR1B1PDE4A | |
| SCHEMBL5496627 | 0.80 | LMNA (0.42) | LMNAL3MBTL1TDP1AKR1B1PDE4A | |
| SCHEMBL3651875 | 0.80 | LMNA (0.42) | LMNAL3MBTL1TDP1AKR1B1PDE4A | |
| SCHEMBL183848 | 0.80 | LMNA (0.34) | LMNAL3MBTL1TDP1AKR1B1PDE4A | |
| SCHEMBL9476977 | 0.79 | LMNA (0.42) | LMNAL3MBTL1TDP1AKR1B1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6987092-B1 | cell membrane penetrating, oxygen-substituted indirubin-3'-monooximes; improved water solubility; anticarcinogenic, antitumor agents for solid cancers | FAUSTUS FORSCHUNGS CIE. TRANSLATIONAL CANCER RESEARCH GMBH (DE) | 2006-01-17 | — | — | US | disclosed |
| CN-1355789-A | Indigoid bisindole derivatives | GERHARD EISENBRAND (DE) | 2002-06-26 | — | — | CN | disclosed |
| EP-1169305-A1 | INDIGOID BISINDOLE DERIVATIVES | Eisenbrand, Gerhard, Prof. Dr. (DE) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000061555-A1 | INDIGOID BISINDOLE DERIVATIVES | EISENBRAND GERHARD (DE) | 2000-10-19 | — | — | WO | disclosed |