Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PRF1 | P14222 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087932 | 1.00 | KDM4E (0.45) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL6090148 | 0.90 | PRF1 (0.38) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL6088857 | 0.90 | PRF1 (0.38) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL6090153 | 0.90 | PRF1 (0.38) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL6088851 | 0.90 | PRF1 (0.38) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL6089196 | 0.85 | SIRT1 (0.46) | MAPTNPC1RAB9ACYP1A2CYP2D6 | |
| SCHEMBL6089199 | 0.85 | SIRT1 (0.46) | MAPTNPC1RAB9ACYP1A2CYP2D6 | |
| SCHEMBL6091179 | 0.78 | SMN1; SMN2 (0.38) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL6089367 | 0.77 | PRF1 (0.44) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL6091646 | 0.77 | SIRT1 (0.42) | MAPTNPC1RAB9AALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |