Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRF1 | P14222 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090148 | 1.00 | PRF1 (0.38) | PRF1CYP19A1LOXL2MAOBCA2 | |
| SCHEMBL6088857 | 0.90 | PRF1 (0.38) | PRF1CYP19A1CNR1KDM4ENPC1 | |
| SCHEMBL6088851 | 0.90 | PRF1 (0.38) | PRF1CYP19A1CNR1KDM4ENPC1 | |
| SCHEMBL6087938 | 0.90 | KDM4E (0.45) | PRF1MAOBKDM4ENPC1MAPT | |
| SCHEMBL6087932 | 0.90 | KDM4E (0.45) | PRF1MAOBKDM4ENPC1MAPT | |
| SCHEMBL6091646 | 0.84 | SIRT1 (0.42) | PRF1MAOBNPC1MAPTRAB9A | |
| SCHEMBL6090355 | 0.84 | SIRT1 (0.42) | PRF1MAOBNPC1MAPTRAB9A | |
| SCHEMBL6089367 | 0.76 | PRF1 (0.44) | PRF1LOXL2MAOBCA2KDM4E | |
| SCHEMBL6089363 | 0.76 | PRF1 (0.44) | PRF1LOXL2MAOBCA2KDM4E | |
| SCHEMBL6089199 | 0.75 | SIRT1 (0.46) | MAOBNPC1MAPTRAB9ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |