Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087021 | 0.90 | CSNK1D (0.56) | SMN1; SMN2KDM4EHTTALDH1A1NPC1 | |
| SCHEMBL6086620 | 0.86 | ALDH1A1 (0.60) | SMN1; SMN2KDM4EHTTALDH1A1NPC1 | |
| SCHEMBL6087865 | 0.84 | ALDH1A1 (0.58) | SMN1; SMN2KDM4EHTTALDH1A1NPC1 | |
| SCHEMBL6088091 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4EHTTALDH1A1NPC1 | |
| SCHEMBL6089264 | 0.81 | ALDH1A1 (0.54) | SMN1; SMN2KDM4EHTTALDH1A1NPC1 | |
| SCHEMBL6091208 | 0.80 | ALDH1A1 (0.56) | SMN1; SMN2KDM4EHTTALDH1A1NPC1 | |
| SCHEMBL6087663 | 0.78 | ALDH1A1 (0.55) | SMN1; SMN2KDM4EHTTALDH1A1NPC1 | |
| SCHEMBL6087544 | 0.77 | ALDH1A1 (0.50) | SMN1; SMN2KDM4EHTTALDH1A1NPC1 | |
| SCHEMBL6086989 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2KDM4EHTTALDH1A1NPC1 | |
| SCHEMBL6088539 | 0.76 | SMN1; SMN2 (0.48) | SMN1; SMN2KDM4EHTTALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109224-B2 | Acyl guanidine compounds and use thereof | BRISTOL-MYERS SQUIBB CO. (US) | 2006-09-19 | — | — | US | disclosed |
| US-20040132750-A1 | Acyl guanidine compounds and use thereof | BRISTOL-MYERS SQUIBB COMPANY | 2004-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132750-A1 | Acyl guanidine compounds and use thereof | ARGLU1, GUCY1A1, GMPS | SMN1; SMN2 957/4885KDM4E 841/4885HTT 3027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.