Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.46 |
| ▸ | BCL2 | P10415 | 3/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5788421 | 1.00 | HTR7 (0.55) | HTR7ALOX5MCL1BCL2MCHR1 | |
| SCHEMBL6089075 | 1.00 | HTR7 (0.55) | HTR7ALOX5MCL1BCL2MCHR1 | |
| SCHEMBL25423999 | 0.90 | MEN1 (0.51) | ALOX5MEN1RAB9AKMT2ANPC1 | |
| SCHEMBL30488393 | 0.90 | MEN1 (0.51) | ALOX5MEN1RAB9AKMT2ANPC1 | |
| SCHEMBL25424003 | 0.90 | MEN1 (0.51) | ALOX5MEN1RAB9AKMT2ANPC1 | |
| SCHEMBL19172461 | 0.81 | HTR7 (0.65) | HTR7ALOX5MCL1BCL2MCHR1 | |
| SCHEMBL3545732 | 0.78 | HTR2A (0.51) | HTR7ALOX5MCHR1MEN1RAB9A | |
| SCHEMBL3545731 | 0.78 | HTR2A (0.51) | HTR7ALOX5MCHR1MEN1RAB9A | |
| SCHEMBL5783787 | 0.78 | HTR2A (0.51) | HTR7ALOX5MCHR1MEN1RAB9A | |
| SCHEMBL23927885 | 0.78 | HTR2A (0.66) | HTR7ALOX5MCL1BCL2MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6998489-B2 | Methods of making indazoles | ALCON, INC. (CH) | 2006-02-14 | — | — | US | disclosed |
| US-20040142998-A1 | Methods of making indazoles | ALCON, INC. (CH) | 2004-07-22 | — | — | US | disclosed |
| WO-2002098861-A1 | METHODS OF MAKING 1-(2-AMINOPROPYL)-6-HYDROXYINDAZOLE | ALCON, INC. (CH) | 2002-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142998-A1 | Methods of making indazoles | NAT1, CYP3A5, ALDH3A1 | HTR7 756/4885ALOX5 99/4885MCL1 1007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.