Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27486368 | 0.87 | POLB (0.39) | POLBALOX15HTTCYP1A2CYP2D6 | |
| SCHEMBL4849918 | 0.84 | SCN4A (0.40) | POLBALOX15HTTKMT2AMEN1 | |
| SCHEMBL6088663 | 0.83 | POLB (0.43) | POLBALOX15HTTCYP1A2CYP2D6 | |
| SCHEMBL6088610 | 0.81 | GAA (0.45) | POLBALOX15HTTCYP1A2CYP2C19 | |
| SCHEMBL6089771 | 0.72 | NR4A2 (0.43) | POLBALOX15HTT | |
| SCHEMBL6087632 | 0.72 | ORAI1 (0.48) | POLBALOX15HTTCYP1A2KMT2A | |
| SCHEMBL30400094 | 0.72 | ORAI1 (0.48) | POLBALOX15HTTCYP1A2KMT2A | |
| SCHEMBL27498821 | 0.72 | POLB (0.37) | POLBALOX15HTTKMT2AMEN1 | |
| SCHEMBL4848408 | 0.69 | SCN4A (0.47) | POLBALOX15HTTKMT2AMEN1 | |
| SCHEMBL15129655 | 0.69 | KDM4E (0.33) | KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |