SCHEMBL6089471

SCHEMBL6089471

O=C1NN=C(C2CC2)C1=Cc1cc2ccccc2[nH]1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIRT1 Q96EB6 1/20 0.50
CYP2A6 P11509 1/20 0.43
AMY1A P0DUB6 1/20 0.41
MAOB P27338 2/20 0.41
MAPT P10636 1/20 0.37
IDO1 P14902 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2D6 P10635 1/20 0.37
MAPK1 P28482 1/20 0.37
CYP2C19 P33261 1/20 0.37
PRF1 P14222 1/20 0.36
MAP4K1 Q92918 6/20 0.36
GRIN2D O15399 1/20 0.33
GRIN3B O60391 1/20 0.33
GRIN1 Q05586 1/20 0.33
GRIN2A Q12879 1/20 0.33
GRIN2B Q13224 1/20 0.33
GRIN2C Q14957 1/20 0.33
GRIN3A Q8TCU5 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6089464 1.00 SIRT1 (0.50) SIRT1CYP2A6AMY1AMAOBMAPT
SCHEMBL6090625 0.88 SIRT1 (0.44) SIRT1CYP2A6AMY1AMAOBMAPT
SCHEMBL6090631 0.88 SIRT1 (0.44) SIRT1CYP2A6AMY1AMAOBMAPT
SCHEMBL6089207 0.82 PRF1 (0.42) MAOBMAPTCYP1A2MAPK1PRF1
SCHEMBL6089211 0.82 PRF1 (0.42) MAOBMAPTCYP1A2MAPK1PRF1
SCHEMBL6091782 0.81 CYP19A1 (0.41) SIRT1MAOBMAPTNPSR1CA12
SCHEMBL6090236 0.81 SIRT1 (0.48) SIRT1CYP2A6AMY1AMAOBMAPT
SCHEMBL6090235 0.81 SIRT1 (0.48) SIRT1CYP2A6AMY1AMAOBMAPT
SCHEMBL6089770 0.77 KDR (0.55) SIRT1CYP2A6AMY1AMAOBMAPT
SCHEMBL6089777 0.77 KDR (0.55) SIRT1CYP2A6AMY1AMAOBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1218373-A2 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2002-07-03 EP claimed
WO-2001009121-A2 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2001-02-08 WO claimed
US-7060822-B1 2-pyrazolin-5-ones ABBOTT GMBH & CO. KG (DE) 2006-06-13 US disclosed
EP-1218373-A2 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2002-07-03 EP disclosed
WO-2001009121-A2 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2001-02-08 WO disclosed