Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 11/20 | 0.52 |
| ▸ | PGR | P06401 | 10/20 | 0.52 |
| ▸ | NR3C2 | P08235 | 10/20 | 0.52 |
| ▸ | AR | P10275 | 10/20 | 0.52 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089835 | 0.79 | NCOA1 (0.44) | HTTMETKDRALDH1A1SMN1; SMN2 | |
| SCHEMBL6090269 | 0.78 | NR3C1 (0.58) | NR3C1PGRNR3C2ARKEAP1 | |
| SCHEMBL6091033 | 0.78 | NR3C2 (0.57) | NR3C1PGRNR3C2ARKEAP1 | |
| SCHEMBL6090518 | 0.77 | NR3C1 (0.72) | NR3C1PGRNR3C2ARKEAP1 | |
| SCHEMBL6090068 | 0.76 | NR3C1 (0.56) | NR3C1PGRNR3C2ARKEAP1 | |
| SCHEMBL6090942 | 0.76 | NR3C1 (0.55) | NR3C1PGRNR3C2ARKEAP1 | |
| SCHEMBL6091846 | 0.74 | NR3C1 (0.48) | NR3C1PGRNR3C2ARKEAP1 | |
| SCHEMBL6090407 | 0.73 | NR3C1 (0.62) | NR3C1PGRNR3C2ARPLA2G7 | |
| SCHEMBL6090072 | 0.73 | NR3C1 (0.51) | NR3C1PGRNR3C2ARPLA2G7 | |
| SCHEMBL6091761 | 0.73 | NR3C2 (0.46) | NR3C1PGRNR3C2ARPLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235222-A1 | Indole-derivative modulators of steroid hormone nuclear receptors | ELI LILLY AND COMPANY (US) | 2006-10-19 | — | — | US | disclosed |
| EP-1597254-A1 | INDOLE-DERIVATIVE MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | Eli Lilly and Company (US) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004067529-A1 | INDOLE-DERIVATIVE MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | ELI LILLY AND COMPANY (US) | 2004-08-12 | — | — | WO | disclosed |
| WO-2004067529-A1 | INDOLE-DERIVATIVE MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | ELI LILLY AND COMPANY (US) | 2004-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235222-A1 | Indole-derivative modulators of steroid hormone nuclear receptors | NR3C2, NR5A1, MC2R | NR3C1 4/4885PGR 148/4885NR3C2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.