Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.36 |
| ▸ | SRC | P12931 | 6/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.35 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 3/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.31 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | RGS12 | O14924 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088248 | 0.84 | KDR (0.39) | KDRPDGFRBSRCFGFR1PKN1 | |
| SCHEMBL6088068 | 0.84 | KDR (0.54) | KDRPDGFRBSRCFGFR1RET | |
| SCHEMBL6088072 | 0.84 | KDR (0.54) | KDRPDGFRBSRCFGFR1RET | |
| SCHEMBL6091270 | 0.76 | KDR (0.40) | KDRPDGFRBSRCFGFR1PKN1 | |
| SCHEMBL6091525 | 0.75 | LRRK2 (0.36) | KDRLRRK2TLK2 | |
| SCHEMBL6091530 | 0.75 | LRRK2 (0.36) | KDRLRRK2TLK2 | |
| SCHEMBL6090793 | 0.74 | KDR (0.46) | KDRPDGFRBSRCFGFR1PKN1 | |
| SCHEMBL6088365 | 0.73 | KDR (0.47) | KDRPDGFRBSRCFGFR1PKN1 | |
| SCHEMBL6090489 | 0.73 | KDR (0.43) | KDRPDGFRBSRCFGFR1PKN1 | |
| SCHEMBL6088285 | 0.72 | KDR (0.46) | KDRPDGFRBSRCFGFR1PKN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |