Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.33 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090054 | 0.79 | KDR (0.40) | KDRPDGFRBFGFR1SRC | |
| SCHEMBL6090046 | 0.79 | KDR (0.40) | KDRPDGFRBFGFR1SRC | |
| SCHEMBL6088171 | 0.79 | KDR (0.43) | KDRPDGFRBFGFR1SRCPKN1 | |
| SCHEMBL6089729 | 0.79 | KDR (0.43) | KDRPDGFRBFGFR1SRCPKN1 | |
| SCHEMBL6090570 | 0.79 | KDR (0.43) | KDRPDGFRBFGFR1SRCPKN1 | |
| SCHEMBL6089757 | 0.78 | KDR (0.42) | KDRPDGFRBFGFR1SRCPKN1 | |
| SCHEMBL6090793 | 0.78 | KDR (0.46) | KDRPDGFRBFGFR1SRCPKN1 | |
| SCHEMBL6088365 | 0.78 | KDR (0.47) | KDRPDGFRBFGFR1SRCPKN1 | |
| SCHEMBL6088285 | 0.76 | KDR (0.46) | KDRPDGFRBFGFR1SRCPKN1 | |
| SCHEMBL6091313 | 0.75 | KDR (0.50) | KDRPDGFRBFGFR1SRCPKN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |