Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 4/20 | 0.33 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6091525 | 1.00 | LRRK2 (0.36) | LRRK2KDRTLK2 | |
| SCHEMBL6087969 | 0.82 | LRRK2 (0.32) | LRRK2 | |
| SCHEMBL6091251 | 0.80 | PDPK1 (0.40) | LRRK2KDRTLK2 | |
| SCHEMBL6091255 | 0.80 | PDPK1 (0.40) | LRRK2KDRTLK2 | |
| SCHEMBL6089020 | 0.79 | PDPK1 (0.41) | LRRK2TLK2 | |
| SCHEMBL6089634 | 0.79 | KDR (0.55) | KDRTLK2 | |
| SCHEMBL6089018 | 0.79 | PDPK1 (0.41) | LRRK2TLK2 | |
| SCHEMBL6089627 | 0.79 | KDR (0.55) | KDRTLK2 | |
| SCHEMBL6089676 | 0.78 | SIRT1 (0.46) | LRRK2 | |
| SCHEMBL6089672 | 0.78 | SIRT1 (0.46) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | claimed |
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |