Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.52 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.52 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090408 | 0.90 | CYSLTR1 (0.52) | CYSLTR1GPBAR1CYSLTR2ALOX5APALOX5 | |
| SCHEMBL6088398 | 0.90 | CYSLTR1 (0.52) | CYSLTR1GPBAR1CYSLTR2ALOX5APALOX5 | |
| SCHEMBL6089372 | 0.89 | CYSLTR1 (0.62) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL6088899 | 0.89 | GPBAR1 (0.61) | CYSLTR1GPBAR1CYSLTR2ALOX5APALOX5 | |
| SCHEMBL6088575 | 0.85 | CYSLTR1 (0.54) | CYSLTR1GPBAR1CYSLTR2FFAR1AKR1B1 | |
| SCHEMBL6088921 | 0.83 | CYSLTR1 (0.58) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL6090709 | 0.82 | CYSLTR1 (0.55) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL7559431 | 0.82 | CYSLTR1 (0.59) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL6092367 | 0.80 | LMNA (0.48) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL4856376 | 0.80 | CYSLTR1 (0.50) | CYSLTR1GPBAR1CYSLTR2ALOX5APPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |